Tamoxifène et endomètre. A propos de 50 métrorragies

Fifty cases of abnormal uterine bleeding occured among women receiving tamoxifen for breast cancer have been investigated by hysteroscopy and dilatation-curetage. The histopathologic findings were the following: atrophic mucosa (11 cases), hyperplasic mucosa or endometrial polyps (34 cases), endometrial adenocarcinoma (5 cases). These results highlight the potential estrogen-like property so-called paradoxical effect of tamoxifen and its suggested oncogenic risk toward the endometrium.