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Oxidative Stress in Parkinson's Disease
- Source :
- The Open Pathology Journal. 3:38-42
- Publication Year :
- 2009
- Publisher :
- Bentham Science Publishers Ltd., 2009.
-
Abstract
- Parkinson's disease (PD) is a progressive, age-related movement disorder, whose neuropathology is character- ized by degeneration of the afferent pigmented neurons of the substantia nigra. Also associated with PD neuropathology are disrupted iron homeostasis, oxidative stress, and intracellular deposition of alpha-synuclein protein in Lewy bodies. Here we review oxidative stress mechanisms in Parkinson's disease, with emphasis on the relationship between oxidative stress and alpha-synuclein gene expression.
- Subjects :
- Alpha-synuclein
Gerontology
medicine.medical_specialty
Parkinson's disease
business.industry
Substantia nigra
Degeneration (medical)
Neuropathology
Disease
medicine.disease_cause
medicine.disease
nervous system diseases
chemistry.chemical_compound
Endocrinology
nervous system
chemistry
Internal medicine
Medicine
business
Oxidative stress
Intracellular
Subjects
Details
- ISSN :
- 18743757
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- The Open Pathology Journal
- Accession number :
- edsair.doi...........ceed69bae4948b6a31799dc4e485ae0f
- Full Text :
- https://doi.org/10.2174/1874375700903010038