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Oxidative Stress in Parkinson's Disease

Authors :
George Perry
Avi L. Friedlich
Paula I. Moreira
Mark A. Smith
Atsushi Takeda
Akihiko Nunomura
Xiongwei Zhu
Source :
The Open Pathology Journal. 3:38-42
Publication Year :
2009
Publisher :
Bentham Science Publishers Ltd., 2009.

Abstract

Parkinson's disease (PD) is a progressive, age-related movement disorder, whose neuropathology is character- ized by degeneration of the afferent pigmented neurons of the substantia nigra. Also associated with PD neuropathology are disrupted iron homeostasis, oxidative stress, and intracellular deposition of alpha-synuclein protein in Lewy bodies. Here we review oxidative stress mechanisms in Parkinson's disease, with emphasis on the relationship between oxidative stress and alpha-synuclein gene expression.

Details

ISSN :
18743757
Volume :
3
Database :
OpenAIRE
Journal :
The Open Pathology Journal
Accession number :
edsair.doi...........ceed69bae4948b6a31799dc4e485ae0f
Full Text :
https://doi.org/10.2174/1874375700903010038