Short- and Long-Term Clinical Outcomes for Patients with Takotsubo Syndrome Versus Myocardial Infarction: A Report from the Swedish Coronary Angiography and Angioplasty Registry

Aim: The takotsubo syndrome (TS) is a life-threatening acute cardiac syndrome that is difficult to distinguish from myocardial infarction (MI) and for which the natural history, management and outcome remain incompletely understood. The aims of this study were to assess the relative short- and long-term mortality risk of TS versus ST-elevation MI (STEMI) and non STEMI (NSTEMI) and to identify predictors of in-hospital complications and worse prognosis among patients with TS. Methods and Results: Using the nationwide Swedish Angiography and Angioplasty Registry (SCAAR) we identified 117,720 patients who underwent coronary angiography due to TS (N=2,898 [2.5%]), STEMI (N=48,493 [41.2%]) or NSTEMI (N=66,329 [56.3%]) in Sweden between January 2009 and February 2018. Patients with TS were more likely to be women than patients with STEMI or NSTEMI. TS was associated with unadjusted and adjusted 30-day mortality risks that were lower than in STEMI (adjusted hazard ratio [adjHR] 0.60, 95% confidence interval [CI]0.48-0.76, p