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An in vitro model for investigation of vitamin A effects on wound healing
- Source :
- International Journal for Vitamin and Nutrition Research. 91:385-390
- Publication Year :
- 2021
- Publisher :
- Hogrefe Publishing Group, 2021.
-
Abstract
- Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p
- Subjects :
- 0301 basic medicine
Vitamin
Nutrition and Dietetics
business.industry
Angiogenesis
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Inflammation
General Medicine
Pharmacology
In vitro model
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
0302 clinical medicine
chemistry
Hemostasis
Medicine
medicine.symptom
business
Wound healing
Subjects
Details
- ISSN :
- 16642821 and 03009831
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- International Journal for Vitamin and Nutrition Research
- Accession number :
- edsair.doi...........cf053a59215942641536805ba4e1e382