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THE EFFICACY AND SAFETY OF ALIROCUMAB IN PEDIATRIC PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA: ODYSSEY KIDS

Authors :
Marie T. Baccara-Dinet
Aurélie Brunet
Sonia Caprio
Eric Bruckert
Virginie Loizeau
Umesh Chaudhari
Garen Manvelian
Michel Scemama
Stephen R. Daniels
Source :
Journal of the American College of Cardiology. 75:1860
Publication Year :
2020
Publisher :
Elsevier BV, 2020.

Abstract

A Phase 2 dose-finding study ([NCT02890992][1]) evaluated the efficacy, safety, and dose selection of the PCSK9 inhibitor alirocumab in pediatric patients with heterozygous familial hypercholesterolemia (HeFH). Patients (N=42) aged 8–17 years, with body weight ≥25 kg and with HeFH and LDL-C ≥

Details

ISSN :
07351097 and 02890992
Volume :
75
Database :
OpenAIRE
Journal :
Journal of the American College of Cardiology
Accession number :
edsair.doi...........cfdf18309ae955eb38054bea99bebdbb
Full Text :
https://doi.org/10.1016/s0735-1097(20)32487-6