Checkpoint kinase (CHK) 1/2 inhibitor LY2606368 in a phase I, dose-expansion study in patients (pts) with metastatic squamous cell carcinoma (mSCC) of the anus

Authors :: Vivek Subbiah
Aimee K. Lin
Ji Lin
Johanna C. Bendell
David S. Hong
Sarina Anne Piha-Paul
Howard A. Burris
Jeffrey R. Infante
Kathleen N. Moore
Ricardo Martinez
Todd M. Bauer
Cathy Eng
Funda Meric-Bernstam
Lisa Golden
Sameera R. Wijayawardana
Suzanne F. Jones
Source :: Journal of Clinical Oncology. 33:3520-3520
Publication Year :: 2015
Publisher :: American Society of Clinical Oncology (ASCO), 2015.
Abstract: 3520 Background: LY2606368 is a CHK 1/2 inhibitor. CHK1 is a multifunctional kinase essential for checkpoint control, DNA repair, cell cycle replication, and proliferation. Potent inhibition of CHK...

Subjects :: Genetics
Cancer Research
animal structures
DNA repair
Kinase
business.industry
Cell cycle
Anus
medicine.anatomical_structure
Oncology
medicine
Cancer research
In patient
Basal cell
biological phenomena, cell phenomena, and immunity
business

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