ChemInform Abstract: Direct Disulfide Formation from 2-Quinolinylmethyl Thioethers with Iron(III) or Copper(II) Salt

2-Quinolinylmethyl thioethers were efficiently cleaved to generate the corresponding symmetrical disulfides using the following systems; FeCl3/N,N-dimethylformamide (DMF)/H2O, FeCl3/ethanol (EtOH)/H2O, and CuCl2/DMF/H2O. The 2-quinolinylmethyl group was utilized as a thiol protecting group in the synthesis of a model peptide.