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Uptake dynamics of scrapie agent in the intestinal villous epithelium of suckling and weanling Syrian hamsters
- Source :
- Microbiology and Immunology. 55:661-665
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- In mice, the number of intestinal villous columnar epithelium cells that incorporate abnormal prion protein (PrP(Sc) ) decreases significantly after weaning. In this study, the dynamics of PrP(Sc) uptake during the growth of hamsters were investigated by inoculating scrapie 263K agent orally into suckling and weanling Syrian hamsters and estimating the number of PrP(Sc) -positive villous epithelium cells immunohistochemically. The number of PrP(Sc) -positive cells declined significantly as the hamsters aged. The present results suggest that a tendency toward decline of PrP(Sc) -positive cells with increasing age might be a common phenomenon among the superfamily Muridae.
- Subjects :
- medicine.medical_specialty
Pathology
biology
animal diseases
Immunology
Weanling
Hamster
Scrapie
biology.organism_classification
Microbiology
Epithelium
nervous system diseases
medicine.anatomical_structure
Endocrinology
Intestinal mucosa
Virology
Internal medicine
medicine
Immunohistochemistry
Mesocricetus
Muridae
Subjects
Details
- ISSN :
- 03855600
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Microbiology and Immunology
- Accession number :
- edsair.doi...........d261827f84e8d0120bb3f63adc31aece