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Uptake dynamics of scrapie agent in the intestinal villous epithelium of suckling and weanling Syrian hamsters

Authors :
Takashi Yokoyama
Masayoshi Yukawa
Yasuhisa Ano
Tomoko Iseki
Takashi Onodera
Akiko Tashiro
Yukita Sato
Atushi Umematu
Misuzu Okano
Ryoko Toyoshima
Tetsutaro Sata
Jyuri Kono
Source :
Microbiology and Immunology. 55:661-665
Publication Year :
2011
Publisher :
Wiley, 2011.

Abstract

In mice, the number of intestinal villous columnar epithelium cells that incorporate abnormal prion protein (PrP(Sc) ) decreases significantly after weaning. In this study, the dynamics of PrP(Sc) uptake during the growth of hamsters were investigated by inoculating scrapie 263K agent orally into suckling and weanling Syrian hamsters and estimating the number of PrP(Sc) -positive villous epithelium cells immunohistochemically. The number of PrP(Sc) -positive cells declined significantly as the hamsters aged. The present results suggest that a tendency toward decline of PrP(Sc) -positive cells with increasing age might be a common phenomenon among the superfamily Muridae.

Details

ISSN :
03855600
Volume :
55
Database :
OpenAIRE
Journal :
Microbiology and Immunology
Accession number :
edsair.doi...........d261827f84e8d0120bb3f63adc31aece