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Dupilumab as a novel steroid-sparing treatment for IgG4-related disease
- Source :
- Annals of the Rheumatic Diseases. 79:549-550
- Publication Year :
- 2019
- Publisher :
- BMJ, 2019.
-
Abstract
- IgG4-related disease (IgG4-RD) is a rare fibroinflammatory, multisystemic condition with a relapsing-remitting progression.1 The level of serum IgG4 correlates with inflammatory activity and organ involvement.1 Glucocorticoids are first line for IgG4-RD, but there are numerous adverse effects with chronic use.2 Dupilumab is a monoclonal antibody that acts on the interleukin 4 (IL-4) receptor alpha, shared by the IL-4 and IL-13 receptors.1 IL-4 causes isotype switching from IgM to IgG4 and IL-13 is implicated in fibrosis.3 Thus, it was postulated by the authors to investigate dupilumab as a novel steroid-sparing treatment for IgG4-RD. A 67-year-old man with no known allergies and a history of sensory neural hearing loss, recurrent bronchitis, spinal stenosis, moderate positional obstructive sleep apnoea, asthma, atopic dermatitis (which caused swelling around his eyes) and allergic rhinoconjunctivitis underwent extensive investigations over the past 2 years due to suspected IgG4-RD. The patient’s initial complaint was pruritic erythematous lesions on the legs, arms, chest and palms. …
- Subjects :
- medicine.medical_specialty
Allergy
integumentary system
Recurrent bronchitis
business.industry
Immunology
Atopic dermatitis
medicine.disease
Dupilumab
Dermatology
General Biochemistry, Genetics and Molecular Biology
Rheumatology
Immunoglobulin class switching
parasitic diseases
Immunology and Allergy
Medicine
IgG4-related disease
business
Adverse effect
Asthma
Subjects
Details
- ISSN :
- 14682060 and 00034967
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Annals of the Rheumatic Diseases
- Accession number :
- edsair.doi...........d36ecea0a1cee80aeaa2ded7cae8cebf