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P 15: Low serum levels of L-Selectin as markers of silent myocardial ischemia and endothelial dysfunction in type 2 diabetic patients
- Source :
- Diabetes & Metabolism. 38:S109
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Introduction In a pilot study we previously suggested that a low serum level of soluble L-Selectin, a protein involved in leucocyte adhesion, might be a marker of coronary artery disease in type 2 diabetic patients (T2D). The aim was to confirm this result in a larger cohort and to explore the association with endothelial dysfunction. Patients and Methods L-Selectin was measured in 364 (230 men) asymptomatic patients with T2D for 13.3±7.0 years, 59.9±8.5 years old, with at least one associated cardiovascular risk factor: hypertension 77.1%, dyslipidemia 70.8%, smoking 22.8%, incipient nephropathy 40.8%, peripheral occlusive arterial disease 13.0%, cardiac autonomic neuropathy (assessed on three standard tests) 74.0%. Silent myocardial ischemia (SMI) was detected by stress myocardial scintigraphy in 135 patients, and 45 of them had significant coronary stenoses on angiography. Results L-Selectin levels were lower in the patients with than in those without SMI (788±218 vs 853±244 ng/ml, p Conclusion Serum levels of L-Selectin are low in T2D patients with SMI. This change may account for leucocytes adhesion on activated endothelium, as suggested by the negative correlation between L-Selectin and albuminuria. The association hypertension - cardiac autonomic neuropathy may play a role in endothelium dysfunction.
- Subjects :
- medicine.medical_specialty
biology
Endothelium
business.industry
Endocrinology, Diabetes and Metabolism
General Medicine
medicine.disease
Asymptomatic
Coronary artery disease
Endocrinology
medicine.anatomical_structure
Internal medicine
Internal Medicine
Albuminuria
biology.protein
Cardiology
Medicine
L-selectin
medicine.symptom
Endothelial dysfunction
Risk factor
business
Dyslipidemia
Subjects
Details
- ISSN :
- 12623636
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Diabetes & Metabolism
- Accession number :
- edsair.doi...........d38027b8e4766be4fc4020cf9a53986e