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Sleep is required for odor exposure to consolidate memory and remodel olfactory synapses

Authors :
Rashmi Chandra
Fatima Farah
Fernando Muñoz-Lobato
Anirudh Bokka
Kelli L. Benedetti
Chantal Brueggemann
Fatema Saifuddin
Julia M. Miller
Joy Li
Eric Chang
Aruna Varshney
Vanessa Jimenez
Anjana Baradwaj
Cibelle Nassif
Sara Alladin
Kristine Andersen
Angel J. Garcia
Veronica Bi
Sarah K. Nordquist
Raymond L. Dunn
Kateryna Tokalenko
Emily Soohoo
Vanessa Garcia
Sukhdeep Kaur
Malcolm Harris
Fabiola Briseno
Brandon Fung
Andrew Bykov
Hazel Guillen
Decklin Byrd
Emma Odisho
Bryan Tsujimoto
Alan Tran
Alex Duong
Kevin C. Daigle
Rebekka Paisner
Carlos E. Zuazo
Matthew A. Churgin
Christopher Fang-Yen
Martina Bremer
Saul Kato
Noëlle D. L’Étoile
Miri K. VanHoven
Publication Year :
2020
Publisher :
Cold Spring Harbor Laboratory, 2020.

Abstract

SUMMARYAnimals with complex nervous systems demand sleep for memory consolidation and synaptic remodeling. Here we show that though theCaenorhabditis elegansnervous system has a limited number of neurons, sleep is necessary for both processes. In addition, it is unclear in any system if sleep collaborates with experience to alter synapses between specific neurons and whether this ultimately affects behavior.C. elegansneurons have defined connections and well-described contributions to behavior. We show that spaced odor-training and post-training sleep induce long-term memory. Memory consolidation, but not acquisition, requires a pair of interneurons, the AIYs, which play a role in odor-seeking behavior. In worms that consolidate memory, both sleep and odor conditioning are required to diminish inhibitory synaptic connections between the AWC chemosensory neurons and the AIYs. Thus, we demonstrate in a living organism that sleep is required for events immediately after training that drive memory consolidation and alter synaptic structures.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........d3b514ed5b466e5bbf6148d821f3b71c
Full Text :
https://doi.org/10.1101/2020.11.24.395228