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Covid-19 in Liver Transplant Recipients: An Italian Case-Control Double-Centre Study

Covid-19 in Liver Transplant Recipients: An Italian Case-Control Double-Centre Study

Authors :
Maria Guarino
Valentina Cossiga
Ilaria Loperto
Ilaria Esposito
Rosanna Ortolani
Andrea Fiorentino
Giuseppina Pontillo
Lucia De Coppi
Valentina Cozza
Alfonso Galeota Lanza
Giovanni Giuseppe Di Costanzo
Francesco Paolo Picciotto
Filomena Morisco
Publication Year :
2021
Publisher :
Research Square Platform LLC, 2021.

Abstract

Background and Aims: Liver transplant (LT) recipients are vulnerable to SARS-CoV-2-infection (COVID-19), due to immunosuppression and comorbidities. This study aimed to evaluate the impact of COVID-19 on LT recipients compared to general population in the Campania region.Methods: In this case-control double-centre study, we enrolled all consecutive adult LT recipients with confirmed SARS-CoV-2-infection. Data were collected at diagnosis of COVID-19 and during follow-up and compared with the regional population. Results: Thirty LT recipients (3.28%) developed SARS-CoV-2-infection (76.6% male, median age 62.6 years). Sixteen (53.3%) were symptomatic. Common symptoms were fever, cough, fatigue, and anosmia. Twenty-five (83.4%) were outpatients, 5 (16.6%) required hospitalization (6.6% admitted to Intensive Care Unit, 6.6% developed Acute Respiratory Distress Syndrome and 6.6% died). Immunosuppressors were in 3 (10%) patients. Incidence rate of COVID-19 was similar between LT patients and general population (3.28% vs 4.37%, p=0.1) with higher rate of symptoms in LT patients (46.67% vs 15.87%, pConclusions: LT is not a risk factor for acquiring COVID-19. Nonetheless, LT patients are more frequently symptomatic, although comparable to the general population for hospitalization rate and mortality.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........d471602121e28c6385846b7632c09def
Full Text :
https://doi.org/10.21203/rs.3.rs-823222/v1