Response to Letter by Moll Regarding Article, 'Hemostatic Therapy in Experimental Intracerebral Hemorrhage Associated With the Direct Thrombin Inhibitor Dabigatran'

Response: We appreciate the interest of Dr Moll1 in our experimental study in which we examined the effect of different hemostatic approaches on early hematoma growth in mice treated with dabigatran etexilate. In contrast to another recently published article2 using a similar experimental model, treatment with high doses of dabigatran in our study induced an excess early hematoma growth compared with nonanticoagulated mice, which we documented by serial MRI. Moreover, we showed that prothrombin complex (PCC) was the most consistently effective agent preventing the excess hematoma growth in mice treated with either 4.5 mg/kg or 9 mg/kg of dabigatran etexilate intraperitoneally. Finally, we tested the effect of 3 different doses of PCC on …