Periodontal regeneration and FGF-2

Periodontal diseases are highly prevalent inflammatory diseases that lead to a destruction of tooth-supporting tissues, such as the periodontal ligament, alveolar bone and cementum, and ultimately result in tooth loss. Conventional treatment for periodontal diseases is the mechanical removal of the periodontal biofilm, which although effective in reducing inflammation in lesion sites, dose not allow regeneration of lost tissues. Therefore, it is important that new therapeutic procedures that encourage the regeneration of periodontal tissues destroyed by periodontal disease will be established. In recent years, the efficacy of topical application of recombinant cytokines for periodontal regeneration has been investigated. This review focuses on the biological activities of FGF-2 in promoting periodontal tissue regeneration. Rec.4/7/2012, Acc.7/22, pp72-77