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Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles
- Source :
- Organic Chemistry Frontiers. 5:2805-2809
- Publication Year :
- 2018
- Publisher :
- Royal Society of Chemistry (RSC), 2018.
-
Abstract
- A concise and enantioselective procedure for the synthesis of optically active indolines has been developed through intramolecular condensation, deprotection and palladium-catalyzed asymmetric hydrogenation in a one-pot process with up to 96% ee. A strong Bronsted acid played an important role in both the formation of indoles and asymmetric hydrogenation process. This strategy could be scaled-up with excellent reactivity and enantioselectivity.
- Subjects :
- In situ
010405 organic chemistry
Chemistry
Organic Chemistry
Asymmetric hydrogenation
Condensation
Enantioselective synthesis
Optically active
010402 general chemistry
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Intramolecular force
Reactivity (chemistry)
Brønsted–Lowry acid–base theory
Subjects
Details
- ISSN :
- 20524129
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Organic Chemistry Frontiers
- Accession number :
- edsair.doi...........d55f40a1936a6228b47c20b9a4ebee04