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Rectal Absorption Enhancement of Oxaprozin Using Solid Dispersion with Polyvinylpyrrolidone

Authors :
Kazuhisa Tanabe
Soichi Itoh
Kayo Tomosada
Yasuko Nakano
Masaru Yamazaki
Tatuyuki Iwasaki
Source :
Japanese Journal of Hospital Pharmacy. 20:509-514
Publication Year :
1994
Publisher :
Japanese Society of Pharmaceutical Health Care and Sciences, 1994.

Abstract

Oxaprozin (OXP) suppositories were prepared and their characteristics were investigated. In vivo rectal absorption studies were carried out in rats by measuring the plasma concentrations of OXP. The amorphous state of OXP with polyvinylpyrrolidone (PVP) was obtained using the dissolving method, and the effect of this solid dispersion on the dissolution of OXP was determined. Enhanced rectal absorption of OXP in the amorphous state was not observed in the OXP-PVP solid dispersion system. By using the pH controlled method, a 6-fold effective increase in Cmax was obtained. The increased bioavailability of OXP resulted in a modification of the dissolution characteristics of OXP by an internal buffer system with Na2HPO4.

Details

ISSN :
21859477 and 03899098
Volume :
20
Database :
OpenAIRE
Journal :
Japanese Journal of Hospital Pharmacy
Accession number :
edsair.doi...........d5d48ff06202fea2d0133bc3116bedae
Full Text :
https://doi.org/10.5649/jjphcs1975.20.509