INFLUENCE OF ANTIOXIDANT CORRECTION ON THE CONDITION OF OXIDATIVE HOMEOSTASIS IN WOMEN SUFFERING FROM PELVIS INFLAMMATORY DISEASES

Aim. The effectiveness of antioxidant correction of oxidative disturbances in women suffering from inflammatory diseases of the small pelvis was evaluated. Materials and methods. The study was performed on 154 women divided into groups: the control group (n=30), the group composed of the patients suffering from the complex course of chronic inflammatory uterine disease with salpingitis and oophoritis in their exacerbation phase (n=120). The patients of the 2nd group underwent standardized course of treatment, while the patients of the 3rd group received tocopherol and retinol in addition to the standard- ized therapy, the patients of the 4th group were injected with the sodium thiosulfate, and the patients of the 5th group received all three antioxidants at the same time. The study lasted 2 weeks, at the beginning and in the end blood and oral liquid were sampled. In the body liquids the general antioxidative activity and the content of oxidative modifications of biomolecules were determined (TBA-reactive substances). Results. The performed study demonstrated the presence of imbalance in oxidative homeostasis in women suf- fering from inflammatory diseases of the small pelvis which was characterized by the general antioxidant activity of the blood plasma decreased by 30% and the content of TBA-reactive substances in erythrocytic meal and oral liquid increased by 45%. The injections of tocopherol, retinol and thiosulfate were accompanied by the similarly expressed stabilization of the prooxidant-oxidative balance including the increase in the general antioxidant activity at the sys- temic level and the decrease in the content of TBA-reactive substances in blood and oral liquid down to the proper indices of the group composed of apparently healthy female test patients. Conclusion. The received data demonstrated the necessity of correction for the imbalance of prooxidant-oxidative system while the evaluation of the correction by means of the lipophilic tocopherol and retinol, hydrophilic sodium thio- sulfate or their combined usage revealed the high effectiveness of each of the used treatment profiles.