RELATIVE SHARE OF alpha1-ADRENOCEPTOR SUBTYPE GENE EXPRESSION IN HUMAN DETRUSOR TISSUE ASSOCIATED WITH BLADDER OUTLET OBSTRUCTION (BOO) AND DETRUSOR INSTABILITY (DI)

tension of approximately 1 mN was applied to preparations that were then left to equilibrate for 60-90 min until spontaneous phasic contractions, which were stable in both amplitude and frequency, were generated. 24 patients (median age 65.1 +/9.3 years) pathologically diagnosed with BPH were used on data analysis. RESULTS: Spontaneous contractions were observed at a frequency of 10.1 +/9.5 5min-1. The amplitude and the rate of the spontaneous contractions were increased by phenylephrine 1.0μM, and were decrease by SIN-1 10μM. The spontaneous contractions