Sorry, I don't understand your search. ×
Back to Search Start Over

Histone acetylation/deacetylation inCandida albicansand their potential as antifungal targets

Histone acetylation/deacetylation inCandida albicansand their potential as antifungal targets

Authors :
Xiuyun Li
Yiman Li
Xinmei Yang
Shan Su
Shuang Jia
Shujuan Sun
Xueqi Chen
Source :
Future Microbiology. 15:1075-1090
Publication Year :
2020
Publisher :
Future Medicine Ltd, 2020.

Abstract

Recently, the incidence of invasive fungal infections has significantly increased. Candida albicans (C. albicans) is the most common opportunistic fungal pathogen that infects humans. The limited number of available antifungal agents and the emergence of drug resistance pose difficulties to treatment, thus new antifungals are urgently needed. Through their functions in DNA replication, DNA repair and transcription, histone acetyltransferases (HATs) and histone deacetylases (HDACs) perform essential functions relating to growth, virulence, drug resistance and stress responses of C. albicans. Here, we summarize the physiological and pathological functions of HATs/HDACs, potential antifungal targets and underlying antifungal compounds that impact histone acetylation and deacetylation. We anticipate this review will stimulate the identification of new HAT/HDAC-related antifungal targets and antifungal agents.

Details

ISSN :
17460921 and 17460913
Volume :
15
Database :
OpenAIRE
Journal :
Future Microbiology
Accession number :
edsair.doi...........d69d8006e1bdd7636e1ea090ce96f98d
Full Text :
https://doi.org/10.2217/fmb-2019-0343