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Histone acetylation/deacetylation inCandida albicansand their potential as antifungal targets
Histone acetylation/deacetylation inCandida albicansand their potential as antifungal targets
- Source :
- Future Microbiology. 15:1075-1090
- Publication Year :
- 2020
- Publisher :
- Future Medicine Ltd, 2020.
-
Abstract
- Recently, the incidence of invasive fungal infections has significantly increased. Candida albicans (C. albicans) is the most common opportunistic fungal pathogen that infects humans. The limited number of available antifungal agents and the emergence of drug resistance pose difficulties to treatment, thus new antifungals are urgently needed. Through their functions in DNA replication, DNA repair and transcription, histone acetyltransferases (HATs) and histone deacetylases (HDACs) perform essential functions relating to growth, virulence, drug resistance and stress responses of C. albicans. Here, we summarize the physiological and pathological functions of HATs/HDACs, potential antifungal targets and underlying antifungal compounds that impact histone acetylation and deacetylation. We anticipate this review will stimulate the identification of new HAT/HDAC-related antifungal targets and antifungal agents.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Histone Acetyltransferases
Histone acetylation and deacetylation
biology
DNA repair
030106 microbiology
Drug resistance
biology.organism_classification
Microbiology
Corpus albicans
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
Histone
chemistry
Acetylation
parasitic diseases
biology.protein
Candida albicans
Subjects
Details
- ISSN :
- 17460921 and 17460913
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Future Microbiology
- Accession number :
- edsair.doi...........d69d8006e1bdd7636e1ea090ce96f98d
- Full Text :
- https://doi.org/10.2217/fmb-2019-0343