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Aglaiabbrevins A–D, New Prenylated Bibenzyls from the Leaves of Aglaia abbreviata with Potent PTP1B Inhibitory Activity
- Source :
- CHEMICAL & PHARMACEUTICAL BULLETIN. 65:295-299
- Publication Year :
- 2017
- Publisher :
- Pharmaceutical Society of Japan, 2017.
-
Abstract
- Four new prenylated bibenzyls, named aglaiabbrevins A-D (2, 4-6), were isolated from the leaves of Aglaia abbreviata, along with two known related analogues, 3,5-dihydroxy-2-[3,7-dimethyl-2(E),6-octadienyl]bibenzyl (7) and 3,5-dihydroxy-2-(3-methyl-2-butenyl)bibenzyl (8). The structures of the new compounds were elucidated on the basis of extensive spectroscopic experiments, mainly one and two dimensional (1D- and 2D)-NMR, and the absolute configuration of 5 was determined by the measurement of specific rotation. The isolated compounds were evaluated for their protein tyrosine phosphatase-1B (PTP1B) inhibitory activity. The results showed that compounds 5-7 exhibited more potent PTP1B inhibitory effects with IC50 values of 2.58±0.52, 2.44±0.35, and 2.23±0.14 µM, respectively, than the positive control oleanolic acid (IC50=2.74±0.20 µM). On the basis of the data obtained, these bibenzyls with the longer C-2 prenyl groups may be considered as potential lead compounds for the development of new anti-obesity and anti-diabetic agents. Also, the PTP1B inhibitory effects for prenylated bibenzyls are being reported for the first time.
- Subjects :
- 010405 organic chemistry
Stereochemistry
Absolute configuration
General Chemistry
General Medicine
Inhibitory postsynaptic potential
01 natural sciences
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
chemistry
Prenylation
Drug Discovery
Bibenzyl
Specific rotation
Tyrosine
Oleanolic acid
IC50
Subjects
Details
- ISSN :
- 13475223 and 00092363
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Accession number :
- edsair.doi...........d6c7c24dbbc678c5b200d778867f5402