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[Untitled]
- Source :
- Heart Failure Reviews. 7:327-334
- Publication Year :
- 2002
- Publisher :
- Springer Science and Business Media LLC, 2002.
-
Abstract
- Strong evidence links cardiomyocyte loss to the pathology of some forms of heart failure. Both necrotic and apoptotic modes of cell death have been invoked as the mechanism underlying progressive cardiomyocyte dropout. Nitric oxide (NO) has received particular attention as a candidate reactive oxygen intermediate that influences not only cardiac function, but also cell death elicited by both apoptotic and necrotic mechanisms. NO is produced by resident cardiac cells under stress, and is produced in large quantities by activated immune cells that infiltrate the injured heart. A review of the literature, however, reveals that the actions of NO on apoptotic cell death are complex, especially in the context of heart disease, and that the practical contribution of NO to cell death in heart disease is yet to be defined.
- Subjects :
- Pathology
medicine.medical_specialty
Programmed cell death
Necrosis
Heart disease
Cell growth
business.industry
Context (language use)
medicine.disease
Nitric oxide
chemistry.chemical_compound
chemistry
Apoptosis
Heart failure
medicine
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 13824147
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Heart Failure Reviews
- Accession number :
- edsair.doi...........d6cb7920c7017952fc5de643d21a44d7