AT-4526, A New Quinolone Derivative: Its Clinical Evaluation on Bacterial Respiratory Disease and Diarrhea in Calves

Bacterial respiratory diseases and diarrhea in the calves are causing great economic losses. So, antibacterial agents are often used to prevent and medicate to the diseases. Recently, bacteria resistant to antibiotics are increasing and causing severe problem in clinical field (1, 2). AT-4526, 1-cyclopropyl-5,6,8-trifluoro-l, 4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid, a new quinolone derivative, has broad and potent antibacterial activity, and is not cross-resistanct with antibiotics (3). It is well absorbed and distributed to most tissues of calves by intramuscular (i.m.) administration (4). Therefore, it is suggested that AT-4526 is useful for bacterial diseases in various animals. This report describes the efficacies of AT-4526 against spontaneous bacterial respiratory diseases and diarrhea in calves.
American Association of Bovine Practitioners Proceedings of the Annual Conference, 1992: Volume 3