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Association between cigarette smoking and dyslipidemia
- Source :
- Immuno-analyse & Biologie Spécialisée. 28:195-200
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Summary Objective The purpose of this study was to examine the effect of cigarettes smoking on lipid profile. Methods The initial study was conducted with 300 healthy subjects, among them, 138 non-smokers aged 38.47 ± 21.91 years and 162 smokers aged 35.55 ± 16.03 years. TG, TC, cHDL, cLDL were determined by enzymatic colorimetric method; ApoA1, ApoB, Lp(a) were determined by immunoturbidimetry on Konelab 30™. Results We noted a significant increase in smokers compared to non-smokers, in TG (1.79 ± 1.03 vs. 1.40 ± 1.24 mmol/L; P ≤ 10 −3 ), TC (4.13 ± 1.18 vs. 3.70 ± 1.04 mmol/L; P ≤ 10 −3 ), c-LDL (1.35 ± 0.56 vs. 1.16 ± 0.61 mmol/L; P ≤ 10 −3 ), Lp (a) (230 ± 226 vs. 179 ± 190 UI/L; P = 10 −3 ) and ApoB/ApoA1 (0.83 ± 0.52 vs. 0.52 ± 0.15; P = 0.03) and significant decrease in c-HDL (0.94 ± 0.25 vs. 1.07 ± 0.27 mmol/L; P ≤ 10 −3 ). TG values were higher in heavy than mild smokers (2.30 ± 0.96 vs. 1.63 ± 1.11 mmol/L; P ≤ 10 −3 ) and c-HDL levels decreased particularly in heavy smokers. We found a strong correlation between TC, TG and c-LDL levels and consumption duration ( r = 0.957, r = 0.991, r = 0.954; respectively). Conclusion Cigarette smoking is associated with perturbations in lipid profile, especially low levels of c-HDL, increase of TG which can explain the atherosclerosis risk.
Details
- ISSN :
- 09232532
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Immuno-analyse & Biologie Spécialisée
- Accession number :
- edsair.doi...........d7426429ebdc6acc78f279cf2b196a33