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Synthesis and cytotoxic activity of heterocycle-substituted phthalimide derivatives
- Source :
- Chinese Chemical Letters. 21:902-904
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- A series of heterocycle-substituted phthalimide derivatives were synthesized. Structurally diverse derivatives with heterocyclic rings, including furan, imidazo[1,2-a]pyridine, 1,3,4-thiadiazine, imidazo[2,1-b][1,3,4]thiadiazine, pyrazole, 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine, thiazole and thiazoline, were obtained by the reactions of α-bromoketone intermediate with various nucleophiles containing oxygen, nitrogen and sulfur atom. Their cytotoxic activity was also evaluated against five human cancer cell lines in vitro .
Details
- ISSN :
- 10018417
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Chinese Chemical Letters
- Accession number :
- edsair.doi...........d7b1646f91ce5c6e52e8b3b42a869268