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Protective effects of the dietary supplementation of turmeric (Curcuma longa L.) on sodium arsenite-induced biochemical perturbation in mice

Authors :
Zahangir Alim Saud
Anwarul A. Akhand
Narshad Ali
Khaled Hossain
Seiichiro Himeno
Abedul Haque
Ekhtear Hossain
Kazi Abdus Salam
Abul Fajol
Khairul Islam
Rezaul Karim
Source :
Bangladesh Medical Research Council Bulletin. 36:82-88
Publication Year :
1970
Publisher :
Bangladesh Journals Online (JOL), 1970.

Abstract

The present study was undertaken to evaluate the protective effect of turmeric powder on arsenic toxicity through mice model. Swiss albino male mice were divided into four groups. The first group was used as control, while groups 2, 3, and 4 were treated with turmeric powder (T, 50mg/kg body weight/day), sodium arsenite (Sa, 10mg/kg body weight/day) and turmeric plus Sa (T+Sa), respectively. Results showed that oral administration of Sa reduced the weight gain of the mice compared to the control group and food supplementation of turmeric prevented the reduction of weight gain. Turmeric abrogated the Sa-induced elevation of serum urea, glucose, triglyceride (TG) level and alanine aminotransferase (ALT) activity except the activity of alkaline phosphatase (ALP). Turmeric also prevented the Sa-induced perturbation of serum butyryl cholinesterase activity (BChE). Therefore, ameliorating effect of turmeric on Sa-treated mice suggested the future application of turmeric to reduce or to prevent arsenic toxicity in human. DOI: 10.3329/bmrcb.v36i3.7287Bangladesh Med Res Counc Bull 2010; 36: 82-88

Details

ISSN :
22247238 and 03779238
Volume :
36
Database :
OpenAIRE
Journal :
Bangladesh Medical Research Council Bulletin
Accession number :
edsair.doi...........d7d868ef4b0d922fd647406e7985ab3c
Full Text :
https://doi.org/10.3329/bmrcb.v36i3.7287