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Fluorescent 10B embedded nanodiamonds as 10B delivery agent for boron neutron capture therapy
- Source :
- Journal of Physics D: Applied Physics. 52:26LT01
- Publication Year :
- 2019
- Publisher :
- IOP Publishing, 2019.
-
Abstract
- Boron neutron capture therapy is a powerful anti-cancer treatment, the success of which depends heavily on the boron delivery agent. Enabling the real-time tracing of delivery agents as they move through the body is crucial to the further development of boron neutron therapy. In this study, we fabricate highly bio-compatible boron-10 embedded nanodiamonds using physical ion implantation in conjunction with a two-step annealing process. The red fluorescence of the nanodiamonds allows their use in fluorescence microscopy and in vivo imaging systems, thereby making it possible to conduct tracking in real time. The proposed fluorescent boron-10 embedded nanodiamonds, combining optical visibility and boron-10 transport capability, are a promising boron delivery agent suitable for a wide range of biomedical applications.
- Subjects :
- inorganic chemicals
Boron Delivery Agent
Materials science
Acoustics and Ultrasonics
Annealing (metallurgy)
chemistry.chemical_element
Nanotechnology
02 engineering and technology
Isotopes of boron
021001 nanoscience & nanotechnology
Condensed Matter Physics
Fluorescence
Neutron therapy
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
03 medical and health sciences
Neutron capture
0302 clinical medicine
Ion implantation
chemistry
030220 oncology & carcinogenesis
0210 nano-technology
Boron
Subjects
Details
- ISSN :
- 13616463 and 00223727
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Journal of Physics D: Applied Physics
- Accession number :
- edsair.doi...........d7f54edd553e389a3b81042760ca5e9f