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BDNFMet allele Is Associated With Lower Cognitive Function in Poststroke Rehabilitation
- Source :
- Neurorehabilitation and Neural Repair. 34:247-259
- Publication Year :
- 2020
- Publisher :
- SAGE Publications, 2020.
-
Abstract
- Background and purpose. The identification of a genetic role for cognitive outcome could influence the design of individualized treatment in poststroke rehabilitation. The aim of this study is to determine whether brain-derived neurotrophic factor ( BDNF) Val66Met polymorphism is independently associated with poststroke functional outcome. Methods. A total of 775 stroke patients with genomic data were identified from the Partners HealthCare Biobank, which contains a large number of genotypes from Biobank’s consented patients. Of 775 stroke patients who met the inclusion/exclusion criteria, 86 were enrolled. Functional outcomes were assessed using the Functional Independence Measure scores at the time of admission and discharge. Logistic and linear regression models adjusted for covariate variables, including age, sex, and medical conditions, were used to evaluate the association between BDNF Val66Met and functional outcome. Results. We detected a significant correlation between Met alleles and lower cognitive function at discharge in both ischemic and hemorrhagic stroke patients. Genotyping findings confirmed that BDNF Met allele frequency was higher in contrast to Val/Val allele frequency in lower cognitive functional recovery. Furthermore, after adjusting for covariate variables, BDNF Met alleles were found to be associated with lower cognitive outcome [ P = .003; odds ratio (OR) = 5.95 (1.81-19.52)] and recovery [ P = .006; OR = 3.16 (1.4-7.15)], especially with lower problem solving, expression, and social recovery in all stroke patients. Conclusions. Met allele carriers exhibited impaired poststroke cognitive function. The BDNF genotype may be a useful predictor of cognitive function in inpatient poststroke rehabilitation.
- Subjects :
- Brain-derived neurotrophic factor
medicine.medical_specialty
Rehabilitation
business.industry
medicine.medical_treatment
Cognition
General Medicine
Odds ratio
030204 cardiovascular system & hematology
Functional Independence Measure
03 medical and health sciences
0302 clinical medicine
Internal medicine
Genotype
Medicine
Allele
business
Allele frequency
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15526844 and 15459683
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Neurorehabilitation and Neural Repair
- Accession number :
- edsair.doi...........d8f4f61622ba39398e5242ee71b67659