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Abstract 178: Infarct Growth Rate Depends on Collateral Status in Acute Ischemic Stroke Patients
- Source :
- Stroke. 48
- Publication Year :
- 2017
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2017.
-
Abstract
- Introduction and Hypothesis: Multiple studies have demonstrated no statistically significant association between time after stroke onset and initial infarct volume. Factors other than time may play a role in infarct growth. We sought to investigate association between collateral status and infarct growth rate in acute ischemic stroke (AIS) patients. Methods: We included 130 consecutive patients with CTA showing ICA and/or proximal MCA occlusions who had DWI within 8 hours of stroke onset. Collateral status was categorized into three groups: poor (none or minimal), intermediate (present but < contralateral side) and good (≥ contralateral side). DWI lesion volumes were measured and infarct growth rate was calculated using MRI time after stroke onset. Mann-Whitney test and correlation coefficient were used for statistical analysis. Results: In our 130 patients, 62 female (48%), the average values (mean±SD) were: age 70 ± 17 years, NIHSS 16 ± 6, DWI volume 59 ± 65 mL, time after stroke onset 4 ± 2 hours, and infarct growth rate 17 ± 23 mL/hour. 19 (14.6%) had poor, 75 (57.7%) had intermediate, and 36 (27.7%) had good collaterals. Infarct growth rate and DWI lesion volume were significantly increased with decreased collateral quality (p Conclusion: AIS patients with good collaterals have small initial DWI lesion volumes and slower infarct growth rates. These patients may be candidates for treatment options outside traditional time windows.
- Subjects :
- Advanced and Specialized Nursing
medicine.medical_specialty
Collateral
business.industry
Collateral circulation
Infarct size
Surgery
Stroke onset
Internal medicine
Ischemic stroke
Infarct volume
medicine
Cardiology
cardiovascular diseases
Neurology (clinical)
Cardiology and Cardiovascular Medicine
business
Acute ischemic stroke
Subjects
Details
- ISSN :
- 15244628 and 00392499
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.doi...........d8feaf6675d47079f87b142133ef92d7