Predictive value of m1A-related genes in kidney renal clear cell carcinoma

Background：Kidney renal clear cell carcinoma (KIRC) is a prevalent type of renal malignancy characterized by high mortality rates and poor response to treatment. N1-methyladenosine (m1A) is a type of RNA methylation modification that has received considerable attention due to its crucial roles in various biological functions. With the advancement of genomics and molecular biology, m1A-related genes (m1A RGs) have been confirmed to be intimately connected with the development and occurrence of various tumors. Nevertheless, the role of m1A RGs in KIRC remains poorly understood. Methods：This study aims to investigate the prognostic significance of 10 major m1A RGs in KIRC patients, utilizing data from The Cancer Genome Atlas (TCGA) dataset. A prognostic model was constructed using Lasso regression analysis, and risk scores were calculated. KIRC patients were classified into high- and low-risk groups based on the median of the average risk score. The prognostic value of the model was evaluated using two independent datasets, GSE537574 and GSE265745, by assessing the sensitivity and specificity using Kaplan-Meier survival analysis and receiver operating characteristic curves. Additionally, gene set enrichment analysis was conducted to explore the possible biological behavior and pathways of m1A RGs. Ultimately, 5 m1A RGs were identified to construct the prognostic model. Furthermore, nomogram and decision curve analyses were performed to evaluate the model's predictive performance and clinical application value. Results：Our study demonstrates that the expression of m1A RGs might serve as a prognostic biomarker for KIRC patients and provides a new perspective for cancer prognosis screening in clinical practice.