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Synthesis of star-branched PLA-b-PMPC copolymer micelles as long blood circulation vectors to enhance tumor-targeted delivery of hydrophobic drugs in vivo
- Source :
- Materials Chemistry and Physics. 180:184-194
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Star-branched amphiphilic copolymer nanocarriers with high-density zwitterionic shell show great promise in drug delivery due to their controllable small size and excellent anti-biofouling properties. This gives the hydrophobic cargo with high stability and long blood circulation in vivo . In the present study, star-branched polylactic acid and poly(2-methacryloyloxyethyl phosphorylcholine) copolymers with (AB 3 ) 3 –type architecture (PLA- b -PMPC 3 ) 3 were conceived as drug vectors, and the copolymers were synthesized by an “arm-first” approach via the combination of ring opening polymerization (ROP), atom transfer radical polymerization (ATRP) and the click reaction. The self-assembled star-branched copolymer micelles (sCPM) had an average diameter of about 64.5 nm and exhibited an ultra-hydrophilic surface with an ultralow water contact angle of about 12.7°, which efficiently suppressed the adhesion of serum proteins. In vivo experiments showed that the sCPM loading strongly enhanced the blood circulation time of DiI and the plasma half-life of DiI in sCPM was 19.3 h. The relative accumulation concentration in tumor of DiI delivered by sCPM was 2.37-fold higher than that of PLA-PEG, at 4 h after intravenous injection. These results demonstrated that the star-branched copolymer (PLA- b -PMPC 3 ) 3 is a promising alternative carrier material for intravenous delivery versus classic PEG-modified strategies.
- Subjects :
- Materials science
Atom-transfer radical-polymerization
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
01 natural sciences
Micelle
Ring-opening polymerization
0104 chemical sciences
chemistry.chemical_compound
Polylactic acid
chemistry
Polymer chemistry
Drug delivery
Biophysics
Click chemistry
Copolymer
General Materials Science
Nanocarriers
0210 nano-technology
Subjects
Details
- ISSN :
- 02540584
- Volume :
- 180
- Database :
- OpenAIRE
- Journal :
- Materials Chemistry and Physics
- Accession number :
- edsair.doi...........dadb953308ddd54a5947be827c797946