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Immunolabeling pattern of syndecan-1 expression may distinguish pagetoid Bowen's disease, extramammary Paget's disease, and pagetoid malignant melanomain situ
- Source :
- Journal of Cutaneous Pathology. 31:169-173
- Publication Year :
- 2003
- Publisher :
- Wiley, 2003.
-
Abstract
- The differential diagnosis of pagetoid cells within the epidermis rests primarily between pagetoid Bowen's disease (PBD), extramammary Paget's disease (EPD), and pagetoid malignant melanoma (MIS) in situ. Although morphologic clues are often helpful in differentiating these lesions, the use of immunohistochemistry is often necessary to arrive at the correct diagnosis. Syndecan-1 is a cell-surface proteoglycan that mediates adhesion between cells and the extracellular matrix, and between cells themselves. Twenty-two cases of PBD, four cases of intraepidermal EPD, and 13 cases of MIS were examined for syndecan-1 immunoreactivity. Cell-membrane syndecan-1 immunoreactivity was evident in PBD, cytoplasmic syndecan-1 immunoreactivity was evident in EPD, whereas immunoreactivity for syndecan-1 was not present in MIS. The patterns of syndecan-1 immunoreactivity in these lesions may be a useful adjunct in the differentiation of PBD, EPD, and MIS.
- Subjects :
- Bowen's disease
medicine.medical_specialty
Pathology
animal structures
Histology
business.industry
Melanoma
Anatomical pathology
Dermatology
medicine.disease
behavioral disciplines and activities
Extramammary Paget's disease
Pathology and Forensic Medicine
Syndecan 1
carbohydrates (lipids)
Pagetoid
embryonic structures
medicine
Immunohistochemistry
Differential diagnosis
business
Subjects
Details
- ISSN :
- 03036987
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Journal of Cutaneous Pathology
- Accession number :
- edsair.doi...........dadcf7f4592eb109365853249e6a1fe8