Effect of the synthetic resorcinol derivative of caryophyllene on cholesterol biosynthesis and the functional activity of immune system cells

The synthesis of a water-soluble compound belonging to the group of terpenoids-disodium salt of a resorcinol derivative of caryophyllene-is described. The biological properties of the new compound have been studied in mice in comparison to some native terpenoids and atorvastatin. The synthesized terpenoid (5 mg/mouse) decreases the rate of cholesterol biosynthesis in murine liver. Similar effects were observed for atorvastatin (0.2 mg/mouse) and the native terpenoids (8.5 mg/mouse), except for perillic alcohol (which produced a stimulating action). In addition, the obtained resorcinol derivative of caryophyllene inhibits mitogen-stimulated murine splenic cell proliferation in vitro in a dose-dependent manner. The drug efficacy in this reaction is comparable with that of perillic alcohol and α-terpineol, while being less pronounced than the effect of dipentene and atorvastatin.