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Antimicrobial Susceptibility Testing Performed in RPMI 1640 Reveals Azithromycin Efficacy against Carbapenem-Resistant Acinetobacter baumannii and Predicts In Vivo Outcomes in Galleria mellonella

Authors :
Sarah Miller
Kristine Goy
Rosemary She
Brad Spellberg
Brian Luna
Source :
Antimicrobial Agents and Chemotherapy. 67
Publication Year :
2023
Publisher :
American Society for Microbiology, 2023.

Abstract

Antimicrobial susceptibility testing (AST) in RPMI 1640, a more physiologically relevant culture medium, revealed that a substantial proportion of carbapenem-resistant Acinetobacter baumannii isolates were susceptible to azithromycin, a macrolide antibiotic not currently considered effective against A. baumannii . Experiments using Galleria mellonella validated these in vitro data.

Details

ISSN :
10986596 and 00664804
Volume :
67
Database :
OpenAIRE
Journal :
Antimicrobial Agents and Chemotherapy
Accession number :
edsair.doi...........db87c1dce597a4ec1f6e4e1040518fe6
Full Text :
https://doi.org/10.1128/aac.01320-22