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Tetrahedral Framework Nucleic Acids Loading Ampicillin Improve the Drug Susceptibility against Methicillin-Resistant Staphylococcus aureus
- Source :
- ACS Applied Materials & Interfaces. 12:36957-36966
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- The overuse of antibiotics has led to the emergence of multidrug-resistant pathogens. There is an urgent need to develop alternative therapeutic strategies to reduce mortality and morbidity related to drug-resistant bacterial infections. Self-synthesized tetrahedral framework nucleic acids (tFNAs) are used as the drug loading platform to deliver ampicillin to combat methicillin-resistant Staphylococcus aureus (MRSA) infection. The results of average dimension, zeta potential, transmission electron microscopy, and ultraviolet spectrophotometry showed that tFNAs-ampicillin combined with a sufficient encapsulation rate and good stability. tFNAs-ampicillin had a better affinity to MRSA than free ampicillin because it had a better uptake by MRSA cells. Additionally, tFNAs-ampicillin had a better antibacterial effect and lower levels of resistance development than free ampicillin. The downregulation of genes related to bacterial cell wall synthesis (murA and murZ) and upregulation of a gene related to antibiotic sensibility (PBP2) were responsible for the enhanced killing effect of tFNAs-ampicillin against MRSA.
- Subjects :
- Drug
Penicillin binding proteins
Materials science
medicine.drug_class
media_common.quotation_subject
Antibiotics
02 engineering and technology
biochemical phenomena, metabolism, and nutrition
010402 general chemistry
021001 nanoscience & nanotechnology
medicine.disease_cause
01 natural sciences
Methicillin-resistant Staphylococcus aureus
0104 chemical sciences
Microbiology
Antibiotic resistance
Staphylococcus aureus
Ampicillin
medicine
Nucleic acid
General Materials Science
0210 nano-technology
medicine.drug
media_common
Subjects
Details
- ISSN :
- 19448252 and 19448244
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- ACS Applied Materials & Interfaces
- Accession number :
- edsair.doi...........dcbaa6d261adf6c920545e9a74fcdfdb
- Full Text :
- https://doi.org/10.1021/acsami.0c11249