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A self-assembling CXCR4-targeted pyroptosis nanotoxin for melanoma therapy
- Source :
- Biomaterials Science. 11:2200-2210
- Publication Year :
- 2023
- Publisher :
- Royal Society of Chemistry (RSC), 2023.
-
Abstract
- The self-assembling nanotoxin T22-PE24 that specifically targets CXCR4 was designed to selectively deliver the cytotoxic toxin PE24 to treat CXCR4+ melanoma via activating caspase 3/GSDME pathways in which initially “cold” tumors will become “hot”.
- Subjects :
- Biomedical Engineering
General Materials Science
Subjects
Details
- ISSN :
- 20474849 and 20474830
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Biomaterials Science
- Accession number :
- edsair.doi...........dcff826893707e71fcdeee42e95fcc6e