Thiacdazone Trial for Its Toxicity and Acceptability by Patients on Domiciliary Basis in Korea

1. Forty- six Korean patients have been treated with thiacetazone 150 mg and isoniazid 300 mg daily and another 45patients with isoniazid alone 300mg daily on an ambulatory basis. They were observed for more than 3 months.2. allergic reaction which had to stop treatment temporarily occurred in 5 cases (10. 9% )and an elevated SGOT in 3 cases (6.5%) in the thiacetazone group. There was also one case of significant fall of hemoglobinand white count. None of such case was found in INH group.3. Therapeutic effects of thiacetazonc were favorable, At 3 months of treatment sputum conversion and roentgenographic improvement occurred in 19.6%. 30.4% respectively in thiacetazone group as compared with only 6.7 %. 4.4%in INH group.4. Thiacetazone can be used successfully to certain patients at well equipped and supervised clinics. More experience is needed before advocating its widespread use.