EXPEDIENCY OF ANTIVIRAL THERAPY AT CHILL IN CHILDREN DURING PANDEMIA COVID-19

Purpose - to study particular properties of the course of the infection among hospitalizedchildren depending on the nature of their treatment provided in pre-hospitalizationperiod in order to improve the results of treatment of children with COVID-19.Material and methods. In a random sample 263 children with COVID-19, admittedto the Department of infectious diseases of the Regional Children's Clinical Hospitalof Chernivtsi, have been examined. The first clinical group includes 68 patients thatreceived antiviral treatment as a part of symptomatic therapy (average age 6,5 ± 0,74years, male ratio 54,4%), and the comparison group - 195 children that did not receiveantiviral activity treatment (average age 6,4 ± 0,41 years, male ratio 50,8%).Results. Most patients with COVID-19 presented signs of moderate to severe medicalstate when admitted to hospital. Patients that did not receive any antiviral therapy in thepre-hospitalization period showed delayed body temperature normalization response (onaverage on the 5th day of the treatment) and, starting from the day 10 of hospitalization,experienced elevated body temperature again caused by infectious and inflammatoryprocess as a result of COVID-19 complications. Changes concerning hemostasisinclude an increase of absolute count of platelets in the blood, reduction in plasmarecalcification time and increase of plasma D-dimer levels (p