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Incidence of Hepatocellular Carcinoma in Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis
- Source :
- Digestive Diseases and Sciences. 66:2439-2451
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The risk and determinants of HCC in patients with primary biliary cholangitis (PBC) are unclear. We conducted a systematic review and meta-analysis of the incidence of HCC and risk factors associated with HCC risk among patients with PBC. We searched PubMed, EMBASE, MEDLINE, Cochrane databases and reference lists from relevant articles to identify cohort studies that examined incidence of HCC in patients with PBC from inception through November 2019. A total of 29 studies including 22,615 patients met the eligibility criteria. The median cohort size was 292 patients followed for an average of 76 months. The pooled incidence rate for patients with PBC was 4.17 per 1000 patient-years (95% CI 3.17–5.47). On subgroup analysis, the incidence of HCC in patients with PBC cirrhosis was 15.7 per 1000 patient-years (95% CI 8.73–28.24). The HCC incidence rate was 9.82 per 1000 person-years (95% CI 5.92–16.28) in men and 3.82 per 1000 person-years (95% CI 2.85–5.11) in women. Cirrhosis is the strongest risk factor for HCC in patients with PBC. Male gender was also a risk factor. Our meta-analysis supports current recommendations of HCC surveillance in patients with PBC cirrhosis. Further studies are needed to evaluate risk factors in this population.
- Subjects :
- medicine.medical_specialty
education.field_of_study
Physiology
business.industry
Incidence (epidemiology)
Population
Gastroenterology
Hepatology
medicine.disease
digestive system diseases
03 medical and health sciences
0302 clinical medicine
Primary biliary cirrhosis
030220 oncology & carcinogenesis
Meta-analysis
Internal medicine
Epidemiology
Medicine
030211 gastroenterology & hepatology
Risk factor
business
education
Cohort study
Subjects
Details
- ISSN :
- 15732568 and 01632116
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Digestive Diseases and Sciences
- Accession number :
- edsair.doi...........dda9a9f71e0e9bcd49cdab23edce768c