P–094 Kidney function impairment in primary infertile men

Study question We investigated the prevalence of kidney function impairment in a homogeneous cohort of white-European primary infertile men. Summary answer Mild kidney function impairment characteristics were found in 9% of asymptomatic and unaware patients presenting for primary infertility investigation. What is known already Infertile men have shown a worse overall health status compared to the fertile counterpart. We investigated the prevalence of kidney function impairment in a homogeneous cohort of white-European primary infertile men. Study design, size, duration In this corss-sectional study, complete clinical and laboratories data from a cohort of 557 consecutive men aged >18 years, presenting for primary infertility investigation were analyzed. Participants/materials, setting, methods Comorbidities (as scored with the Charlson Comorbidity Index (CCI)) were collected in each patient. Primary outcome was the presence of functional impairment of the kidney (defined as an estimated glomerular filtration rates Main results and the role of chance Of 557, 51 (9.3%) patients depicted at least a mild loss of kidney function (eGFR 0.05), after accounting for age, CCI, BMI, FSH, testicular volume, and varicocele. Limitations, reasons for caution Mild kidney function impairment characteristics were found in 9% of asymptomatic and unaware patients presenting for primary infertility investigation. Age and the rate of comorbidities are associated with reduced eGFR. Wider implications of the findings: This novel finding confirms growing data on a significant association of male infertility with a poorer overall male health status. Trial registration number Not applicable