Pathological Diagnosis of Mesothelioma

The diagnosis of mesothelioma is one of the most difficult challenges faced by pathologists. Its histologic diagnosis is stepwise and should be based on morphological assessment, associated with clinical and radiological findings, and supported by immunohistochemistry as well as more recent molecular tests. This neoplasm displays a wide variety of histologic patterns and the major dilemmas consist in differential diagnosis with benign mesothelial proliferations and other mimicking malignant tumors.