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Toxicity of Tributyltin in Juvenile Common Carp (Cyprinus Carpio): Physiological Responses, Hepatic Gene Expression, and Stress Protein Profiling
- Source :
- Journal of Biochemical and Molecular Toxicology. 30:91-96
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- In this study, the effects of tributyltin (TBT) on biochemical parameters (antioxidant responses and Na(+) -K(+) -ATPase) in different tissues were investigated by using juvenile common carp (Cyprinus Carpio) as well as growth and ion regulation-related genes expression and stress-related proteins profiling in fish liver. Oxidative stress indices and Na(+) -K(+) -ATPase showed tissues-specific responses in fish exposed to different TBT concentrations. All tested genes related to GH/IGF-I axis and ion-regulation were significantly induced in the TBT group with lower concentrations (except for the igfbp3 in 10 μg/L) and were inhibited in 20 μg/L. In addition, the profiling of two proteins Hsp 70 and MT were increasing in a dose-dependent manner under TBT stress. In short, TBT-induced biochemical and molecular responses in different tissues were reflected in the measured parameters in the test. On the basis of TBT residue levels in the natural environment, more long-term experiments at lower concentrations will be necessary in the future.
- Subjects :
- Antioxidant
Health, Toxicology and Mutagenesis
medicine.medical_treatment
ATPase
0211 other engineering and technologies
02 engineering and technology
010501 environmental sciences
Biology
Toxicology
medicine.disease_cause
Bioinformatics
01 natural sciences
Biochemistry
Cyprinus
Common carp
chemistry.chemical_compound
Gene expression
medicine
Molecular Biology
0105 earth and related environmental sciences
021110 strategic, defence & security studies
General Medicine
biology.organism_classification
Molecular biology
chemistry
Toxicity
biology.protein
Tributyltin
Molecular Medicine
Oxidative stress
Subjects
Details
- ISSN :
- 10956670
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Journal of Biochemical and Molecular Toxicology
- Accession number :
- edsair.doi...........deef9e4e2f4ec0af63a4ea3ae9b88c29