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Synthesis of poly-functionalized imidazoles via vinyl azides annulation

Authors :
Liu Xingyu
Ke Shu
Wenteng Chen
Yongping Yu
Pai Tang
Jing Luo
Jiaan Shao
Source :
RSC Advances. 5:55808-55811
Publication Year :
2015
Publisher :
Royal Society of Chemistry (RSC), 2015.

Abstract

An efficient annulation of vinyl azides with activated imines has been developed for the synthesis of poly-functionalized imidazole derivatives. This reaction includes thermal decomposition of vinyl azides to 2H-azirines, nucleophilic attack of 2H-azirines with activated imines and subsequent cyclization to desired imidazoles.

Details

ISSN :
20462069
Volume :
5
Database :
OpenAIRE
Journal :
RSC Advances
Accession number :
edsair.doi...........dfcbbcd009d8bb9ea6b13851c0a3bf9e
Full Text :
https://doi.org/10.1039/c5ra07320k