Stereoselective Synthesis of Conformationally Constrained Tropane Analogues: 6-Chloro-2,5-diazatetracyclo [8.5.0.02,13.04,9]pentadeca-4,6,8-triene-11-one and 6-Chloro-2,7-diazatetracyclo [8.5.0.02,13.04,9]pentadeca-4,6,8-triene-11-one

Two conformationally constrained tropane derivatives were prepared as rigid nicotinic acetylcholine receptor ligands. A palladium catalyzed intramolecular α-arylation reaction was employed to generate the tricyclic compounds in good yields from N-(bromo-chloropyridylmethyl)-8-azabicyclo[3.2.1]octan-3-ones.