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Rapid resistance profiling of SARS-CoV-2 protease inhibitors

Authors :
Seyed Arad Moghadasi
Rayhan G. Biswas
Daniel A. Harki
Reuben S. Harris
Publication Year :
2023
Publisher :
Cold Spring Harbor Laboratory, 2023.

Abstract

Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a panel of SARS-CoV-2 main protease (Mpro) variants and a robust cell-based assay are used to compare the resistance profiles of nirmatrelvir, ensitrelvir, and FB2001. The results reveal distinct resistance mechanisms (“fingerprints”) and indicate that these next-generation drugs have the potential to be effective against nirmatrelvir-resistant variants andvice versa.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........e06625227bf166e81702f0417e518ffb
Full Text :
https://doi.org/10.1101/2023.02.25.530000