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Rapid resistance profiling of SARS-CoV-2 protease inhibitors
- Publication Year :
- 2023
- Publisher :
- Cold Spring Harbor Laboratory, 2023.
-
Abstract
- Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a panel of SARS-CoV-2 main protease (Mpro) variants and a robust cell-based assay are used to compare the resistance profiles of nirmatrelvir, ensitrelvir, and FB2001. The results reveal distinct resistance mechanisms (“fingerprints”) and indicate that these next-generation drugs have the potential to be effective against nirmatrelvir-resistant variants andvice versa.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........e06625227bf166e81702f0417e518ffb
- Full Text :
- https://doi.org/10.1101/2023.02.25.530000