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Catalyst-free and atom-economical 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines: Facile synthesis of isoquinoline-fused spirocycles
- Source :
- Green Synthesis and Catalysis. 3:69-78
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- A highly efficient and environmentally benign 1,3-dipolar cycloaddition of C, N - cyclic azomethine imines with 5-alkenyl thiazolones and 2-arylidenindane-1,3-diones is developed for the construction of congested quaternary spiro-carbon centers. All these transformations can be smoothly performed in ethanol at room temperature, providing a catalyst-free and atom-economical access to diversely substituted novel isoquinoline-fused spirocycles in almost quantitative yields with high diastereoselectivities. The promising anti-tumor activity of these structurally novel spirocyclic compounds is reported as well.
Details
- ISSN :
- 26665549
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Green Synthesis and Catalysis
- Accession number :
- edsair.doi...........e0a1f875da1c40e41144f7d1c45e4f40
- Full Text :
- https://doi.org/10.1016/j.gresc.2021.11.005