Back to Search
Start Over
Paving the way of systems biology and precision medicine in allergic diseases: the Me <scp>DALL</scp> success story
- Source :
- Allergy. 71:1513-1525
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.
- Subjects :
- 0301 basic medicine
Allergy
education.field_of_study
business.industry
Systems biology
Immunology
Population
Atopic dermatitis
Omics
medicine.disease
Precision medicine
3. Good health
Review article
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
030228 respiratory system
Immunology and Allergy
Medicine
media_common.cataloged_instance
European union
business
education
media_common
Subjects
Details
- ISSN :
- 13989995 and 01054538
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Allergy
- Accession number :
- edsair.doi...........e0dd042b409cd7901a33dbbd20c82865