Diagnostic morphology in multiple myeloma

Multiple myeloma (mm) is characterized by plasma cell infiltration in the bone marrow, suppression of normal haematopoiesis, destruction of bone, renal failure, and recurrent infections. The extent of organ involvement, severity of complications, drug sensitivity and therefore the clinical course differ widely among patients. Specific and reliable laboratory examinations and especially morphology are required to evaluate its aggressivity and extent and for recognition of complications. In this review of MM and its variants we emphasize the impact of morphology in both bone marrow biopsy and aspiration on the diagnostic and prognostic approach to MM, and on the planning of appropriate therapy.