ChemInform Abstract: Preparation of Optically Active (4aα,8aβ)-Octahydro-4a-methyl-8-methylene-2(1H)-naphthalenone, a Key Intermediate for the Enantioselective Synthesis of Eudesmane Sesquiterpenes

Authors :: Masanori Utaka
Yasuyuki Fujii
Akira Takeda
Source :: ChemInform. 18
Publication Year :: 1987
Publisher :: Wiley, 1987.
Abstract: The titled optically active methylene ketone was prepared in 45% ee from 3-methyl-1,2-cyclohexanedione by use of a novel asymmetric Michael addition with (R,R)-(−)-2,3-butanediol as chiral auxiliary.

Subjects :: chemistry.chemical_classification
chemistry.chemical_compound
Chiral auxiliary
Ketone
chemistry
Michael reaction
Enantioselective synthesis
Organic chemistry
General Medicine
Optically active
Methylene

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