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Development and performance evaluation of Time-over-Threshold based digital PET (TODPET2) scanner using SiPM/Ce:GAGG-arrays for non-invasive measurement of blood RI concentrations
- Source :
- Journal of Instrumentation. 12:C02028-C02028
- Publication Year :
- 2017
- Publisher :
- IOP Publishing, 2017.
-
Abstract
- We developed Time-over-Threshold based digital PET (TODPET2) tomograph using silicon photomultipliers (SiPM) arrays coupled with pixelized Ce:Gd3(Ga, Al)5O12 (Ce:GAGG) scintillators dedicated for non-invasive measurement of blood RI concentrations. The detector consists of 1.57 × 1.57 mm2 SiPM chips and 1.6 × 1.6 × 15 mm3 Ce:GAGG scintillators arranged on a 12 × 12 channel, both working as individual readout systems. After the development of the detector, we fabricated the PET gantry composed of 8 pieces of SiPM/Ce:GAGG detector array which signals were sent to the current-comparing type time-over-threshold (TOT) ASIC for individual readout of pixels. The PET scanner which we developed has 25 mm axial field-of-view (FOV) and 60 mm transaxial FOV. The spatial resolution reconstructed with maximum likelihood estimation method (MLEM) is 0.98 mm (FWHM) at the center of FOV. The sensitivity of the system is measured to be 1.31% using 22Na point source. Finally, timing response to changes in RI concentration was also measured using 5 mm diameter syringe injected with several concentrations of 18FDG.
- Subjects :
- Physics
medicine.medical_specialty
Scanner
Pixel
010308 nuclear & particles physics
business.industry
Detector
Scintillator
01 natural sciences
030218 nuclear medicine & medical imaging
03 medical and health sciences
Full width at half maximum
0302 clinical medicine
Silicon photomultiplier
Optics
0103 physical sciences
medicine
Medical physics
Tomography
business
Instrumentation
Image resolution
Mathematical Physics
Subjects
Details
- ISSN :
- 17480221
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Instrumentation
- Accession number :
- edsair.doi...........e29095e3b43f9c7cde837d9dddae24f9