Improved survival in surgical stage I uterine papillary serous cancer (UPSC) treated with adjuvant platinum-based chemoradiation

5023 Objective: UPSC is an aggressive type of endometrial cancer characterized by a high recurrence rate and a poor prognosis. Prior studies evaluating treatment of UPSC are limited by small numbers of patients and inclusion of unstaged patients. The purpose of this study is to evaluate the efficacy of adjuvant chemoradiation (defined as concomitant vaginal cuff radiation and platinum-based chemotherapy) in a large cohort of stage I UPSC patients. Methods: We identified 182 patients with UPSC who underwent complete surgical staging between 1987–2003. Differences in disease free survival (DFS) and overall survival (OS) were determined by Kaplan-Meier log rank method. Results: 74 of the182 cases were FIGO stage I: 33 stage IA, 29 stage IB and 12 stage IC. Stage IA patients were further divided into 2 groups: patients with no cancer in the hysterectomy specimen (defined as no residual uterine disease, n=12) and patients with residual uterine disease (n=21). Stage IA patients with no residual uterine disease ...